A Lower Allred Score for Progesterone Receptor Is Strongly Associated With a Higher Recurrence Score of 21-Gene Assay in Breast Cancer

Ping TangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Jianmin WangRTI Health Solution, Research Triangle Park, North Carolina, USA

David G. HicksDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Xi WangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Linda SchiffhauerDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Loralee McMahonDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Qi YangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Michelle ShayneDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Alissa HustonDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Kristin A. SkinnerDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA

Jennifer GriggsDepartment of Medicine, University of Michigan, Ann Arbor, Michigan, USA

Gary LymanDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

show all

ABSTRACT

Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) –2.408 (PR) –1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R² of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A Lower Allred Score for Progesterone Receptor Is Strongly Associated With a Higher Recurrence Score of 21-Gene Assay in Breast Cancer

Information for

Open access

Opportunities

Help and information

A Lower Allred Score for Progesterone Receptor Is Strongly Associated With a Higher Recurrence Score of 21-Gene Assay in Breast Cancer

ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature