Prognostic Value of E-Cadherin Expression and CDH1 Promoter Methylation in Patients With Endometrial Carcinoma

Tie-Zhong YiDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Jing GuoDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Lili ZhouDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Xing ChenDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Ruo-Ran MiDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Quan-Xin QuDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Jian-Hua ZhengDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, China

Ling ZhaiDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, Department of Obstetrics and Gynecology, Qiqihaer Jianhua Hospital, Qiqihaer, China, Department of Obstetrics and Gynecology, Heilongjiang Provincal Hospital, Harbin, China, Department of Obstetrics and Gynecology, Taizhou Hospital, Zhejiang, China, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Tianjin, ChinaCorrespondence[email protected]

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Abstract

The primary aim of this study is to evaluate the clinical significance of E-cadherin protein expression and the methylation status in CDH1 promoter in endometrial cancer. The expression of E-cadherin and methylation in its promoter region was analyzed, retrospectively, in 152 clinical tissue samples from patients with endometrial lesions. We found that the hypermethylation of CDH1 promoter, which caused low expression of E-cadherin in endometrial cancer, was associated with not only clinicopathological progress of endometrial cancer but also with the overall 5-year clinical survival rate. The findings provide the potential therapeutic and prognostic target molecule for patients with endomethrial cancer.

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ACKNOWLEDGMENT

This work has been supported by Heilongjiang Province Science and Technology Foundation for Youths (QC07C99), China.

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Prognostic Value of E-Cadherin Expression and CDH1 Promoter Methylation in Patients With Endometrial Carcinoma

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Prognostic Value of E-Cadherin Expression and CDH1 Promoter Methylation in Patients With Endometrial Carcinoma

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