Leukotrienes Antagonize the Antiproliferative Effect of Larrea divaricata Cav. on a Lymphoma Cell Line Interfering with cAMP Intracellular Level and PKC Activity

Abstract

Larrea divaricata exerts a dual effect on the proliferation of BW5147 cells. The aim of this work was to analyze the effect of leukotrienes on the antiproliferative action of the extract in relation to cyclic adenosine monophosphate production and protein kinase C activation. The extracts induced cyclic adenosine monophosphate and inhibited protein kinase C but induced leukotriene B4 production, which exerted contrary effects. These results suggest the finding of an extract free of compounds, which can increase leukotriene B4 level, in order to obtain a more active extract to be used in the treatment of lymphomas, positively modulated by leukotrienes.

Keywords: :

• LTB4
• Lymphoma BW5147
• Cyclic adenosine monophosphate
• Protein kinase C
• L. divaricata

ACKNOWLEDGEMENT

This work was supported by funds provided by UBACYT B116 from Buenos Aires University. Roberto Davicino is a postdoctoral fellow of CONICET.