Dysregulation of Betaglycan Expression in Primary Human Endometrial Carcinomas

Piotr K. ZakrzewskiDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Jacek MokrosinskiDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Adam I. CygankiewiczDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Andrzej SemczukDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Tomasz RechbergerDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Danuta SkomraDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, Poland

Wanda M. KrajewskaDepartment of Cytobiochemistry, IInd Departments of Gynecology, and Pathology, Medical University of Lublin, Lublin, PolandCorrespondence[email protected]

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Abstract

TGFβ signaling cascade plays a vital role in neoplastic transformation, but the function of betaglycan, which is a TGFβ accessory receptor, is still unknown in particular cancer. Evaluation of betaglycan expression both at mRNA (real-time PCR) and protein (ELISA) level in the context of TGFβ canonical signaling components, i.e., TGFβ1, TGFβ2, and TGFβRII, in endometrial carcinomas was performed. Betaglycan mRNA expression level was significantly (p < .001) downregulated with simultaneous betaglycan protein level upregulation in cancer samples. Obtained results suggest that endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFβ2-induced signaling.

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ACKNOWLEDGMENT

This work was supported in part by grant 505/0375 from the University of Lodz, Poland.

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Dysregulation of Betaglycan Expression in Primary Human Endometrial Carcinomas

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Dysregulation of Betaglycan Expression in Primary Human Endometrial Carcinomas

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