Improvement of Prostate Cancer Detection by Integrating the PSA Test With miRNA Expression Profiling

Yuan ZhaoDepartment of Oral Diagnostic Service, College of Dentistry, Howard University, Washington, District of Columbia, USA

Xiaoyun ZhaoHebei General Hospital, Hebei, China,

Chunnian HeHebei General Hospital, Hebei, China,

Xiaowu PangDepartment of Oral Diagnostic Service, College of Dentistry, Howard University, Washington, District of Columbia, USA

T.-C. Wu

Joseph A. Califanoand Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, Baltimore, Maryland, USA

Xinbin GuCancer Center, Howard University, Washington, District of Columbia, USA Correspondence[email protected]

show all

Abstract

Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cultured prostate cell lines and 20 human prostate specimens. We found that the miRNA expression profiles were significantly different between nontumorigenic and tumorigenic cell lines and specimens. Positive predictive value analysis of prostate cancer was increased from 40% to 87.5% by integrating patient PSA blood levels with miR-21 and miR-141 profiles.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Improvement of Prostate Cancer Detection by Integrating the PSA Test With miRNA Expression Profiling

Information for

Open access

Opportunities

Help and information

Improvement of Prostate Cancer Detection by Integrating the PSA Test With miRNA Expression Profiling

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature