The Use of Salivary Protein Secretions as an In Vivo Model to Study Mantel Cell Lymphoma Progression and Treatment

Abstract

Purpose: The objective of this study was to compare the salivary protein profiles from an individual diagnosed with MCL before, during, and after chemotherapy. Methods: Saliva specimens acquire prior, during, and after chemotherapy. Specimens were analyzed using a LC-MS/MS mass spectrometer. Results: The results of the study suggest salivary protein alterations secondary to MCL and that a number of the proteins were changed as a result of chemotherapeutic intervention suggesting that the treatment, from a proteomic perspective, was efficacious. The study suggests that salivary secretions may be used as in vivo model for studying MCL progression and treatment efficacy.

Keywords: :

• Mantle cell lymphoma
• Saliva
• Cancer modeling
• Tissue mimicry
• Signaling

ACKNOWLEDGMENTS

The authors thank Dr. William Dubinsky for the LC-MS/MS salivary mass spectrometry analyses.

DECLARATION OF INTERESTS

The authors report no declaration of interest. The authors alone are responsible for the content and writing of the paper.