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ORIGINAL ARTICLE

Distinguishing Patients with Stage I Lung Cancer Versus Control Individuals using Serum Mass Profiling

, , , , , , , , , , & show all
Pages 136-143 | Received 23 Aug 2013, Accepted 11 Jan 2014, Published online: 28 Feb 2014
 

Abstract

Serum mass profiling can discern physiological changes associated with specific disease states and their progression. Sera (86 total) from control individuals and patients with stage I nonsmall cell lung cancer or benign small pulmonary nodules were discriminated retrospectively by serum changes discerned by mass profiling. Control individuals were distinguished from patients with Stage I lung cancer or benign nodules with test sensitivities of 89% and 83%. Lung cancer patients versus those with benign nodules were distinguished with 80% sensitivity. This study exhibits progress toward a minimally-invasive aid in early detection of lung cancer and monitoring small pulmonary nodules for malignancy.

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