HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

M. ZhaoWuxi Maternity and Children Health Hospital, Nanjing Medical University,China,

J. X. DingThe Hospital of Obstetrics & Gynaecology, Fudan University,China,Correspondence[email protected] [email protected]

G. Y. Nie

J. WeiDepartment of Obstetrics & Gynaecology, The University of Auckland,New Zealand,

Y. LiSchool of Interprofessional Health Studies, Auckland University of Technology,New Zealand

X. Y. YinWuxi Maternity and Children Health Hospital, Nanjing Medical University,China,

Q. ChenCorrespondence[email protected] [email protected]

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Abstract

Ovarian cancer is the leading cause of death in gynaecological cancers. The high temperature requirement factor A3 (HtrA3) is involved in the pathogenesis of ovarian cancer. In this study we investigated whetherHtrA3 protein levels were altered in subtypes of ovarian cancer and whether HtrA3 down-regulation was associated with peritoneal metastasis. Ovarian cancer tissues from 89 patients were analyzed by immunohistochemistry. The levels of HtrA3 protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 were in epithelial ovarian cancer. The down-regulation of HtrA3 levels was not correlated with peritoneal metastasis of epithelial ovarian cancer.

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HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

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HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

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