Anti-Metastatic Study of Liposome-Encapsulated All trans Retinoic Acid (ATRA) in B16F10 Melanoma Cells-Implanted C57BL/6 Mice

Abstract

B16F10 cells-induced C57BL/6 mice were divided into several groups and the free all trans retinoic acid (ATRA) and liposome-encapsulated ATRA were given for 21 days. The encapsulated ATRA treatment lowered the oxidative stress and lipid profile near to the normal level in the drug-treated mice. Encapsulated ATRA treatment showed substantial decrease in serum cytokines and increase in lifespan when compared with free ATRA treatment. These results imply that the liposome-encapsulated ATRA may help to achieve a higher level of ATRA in comparison with free ATRA treatment and helps to enhance anticancer drug delivery in liposome-encapsulated ATRA treatment.

Keywords: :

• All trans retinoic acid (ATRA)
• Oxidative stress
• Cytokine
• Liposome
• Lung cancer