Quality and Outcomes of Treatment of Hypercalcemia of Malignancy

Jason D. WrightDepartment of Obstetrics and Gynecology, Columbia University, New York, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USACorrespondence[email protected]

Ana I. TergasDepartment of Obstetrics and Gynecology, Columbia University, New York, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA,

Cande V. AnanthDepartment of Obstetrics and Gynecology, Columbia University, New York, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA,

William M. BurkeDepartment of Obstetrics and Gynecology, Columbia University, New York, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USA

June Y. HouDepartment of Obstetrics and Gynecology, Columbia University, New York, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USA

Ling ChenDepartment of Obstetrics and Gynecology, Columbia University, New York, USA

Alfred I. NeugutHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA,;Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA

Catherine A. RichardsDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA,

Dawn L. HershmanHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA;New York Presbyterian Hospital, New York, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA,;Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA

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Abstract

Using a nationwide database, 4,874 patients with hypercalcemia of malignancy were identified. The in-hospital mortality rate was 6.8%. Overall, 1,971 (40.4%) patients received pamidronate and 1,399 (28.7%) received zoledronic acid during hospitalization. Calcitonin was utilized in 1,337 (27.4%) patients while glucocorticoids were administered to 1,311 (26.9%). Use of contraindicated medications was noted in 136 (2.8%) patients who received thiazide diuretics and 12 (0.2%) who received lithium. Tumor site, presence of bone metastases, and severity of illness were predictors of treatment. There was no association between treatment with bisphosphonates, calcitonin, or glucocorticoids and morbidity or mortality.

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Quality and Outcomes of Treatment of Hypercalcemia of Malignancy

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