Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer

Jens NeumannInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, GermanyCorrespondence[email protected]

Lisa LöhrsDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany

Markus AlbertsmeierDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany

Simone ReuInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany

Markus GubaDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany

Jens WernerDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany

Thomas KirchnerInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany

Martin AngeleDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany

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Abstract

Although peritoneal carcinomatosis (PC) displays advanced stage in colorectal cancer (CRC), most patients present without distant metastases. To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and β-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread. Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC. Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC. These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination.

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Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer

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Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer

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