Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

Bowen ZhouFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada

Anne BlanchardFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada;Faculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, Canada

Nan WangFaculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, Canada

Xiuli MaFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada

Jihyun HanFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada

Ingo SchroedterFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada

Etienne LeygueFaculty of Health Sciences, Department of Biochemistry and Human Genetics, College of Medicine, University of Manitoba, Winnipeg, Canada

Yvonne MyalFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada;Faculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, CanadaCorrespondence[email protected]

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Abstract

Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGFβ. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.

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Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

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Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

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