Circadian Dexras1 in rats: Development, location and responsiveness to light

ABSTRACT

Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at postnatal day 3 and can be detected as early as embryonic day 20. In contrast, its expression in peripheral tissues is not rhythmic in adult rats either. The Dexras1 protein is expressed predominantly in the dorsomedial part of the SCN and the light pulse has only a limited effect on its expression. Our data provide the descriptive basis for speculation about the Dexras1 involvement in the rat circadian physiology.

KEYWORDS:

• Dexras1
• suprachiasmatic nucleus
• rat
• light

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported by the Czech Science Foundation (P303/12/1137), the Ministry of Education, Youth and Sport of the Czech Republic (SVV-260087/2014), the European Regional Development Fund and the state budget of the Czech Republic (Project no. CZ.1.05/4.1.00/16.0347).