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Abstract
A meta-analysis of possible antihypertensive effects of small doses of bioactive tripeptides isoleucine-proline-proline and valine-proline-proline in commercial milk products or tablets was carried out. A random effects model was used on 19 randomized, placebo-controlled clinical intervention trials (published 1996–October 2010) consisting of about 1500 prehypertensive or mildly hypertensive subjects.The overall blood pressure lowering for systolic blood pressure was –4.0 mmHg (95% CI –5.9 to –2.1 mmHg, P < 0.001) and for diastolic blood pressure –1.9 mmHg (95% CI –3.1 to –0.8 mmHg, P < 0.001). However, a positive effect was not reported in all the studies. The results suggest that rather small daily doses of the lactotripeptides in different functional food products may offer a valuable option as a non-pharmacological treatment of prehypertension or mild hypertension as part of life-style advice.
Acknowledgements
We are grateful to Aino Siltari for her excellent technical help in preparing the manuscript.
Declaration of interest: Anu Turpeinen is an employee of Valio Ltd, Riitta Korpela was an employee of Valio Ltd until August 2010, and Heikki Vapaatalo was a consultant to Valio Ltd until December 2010.