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Review Article

Circadian clock disruptions and the risk of cancer

, &
Pages 847-853 | Received 12 Dec 2012, Accepted 18 Jul 2012, Published online: 16 Oct 2012
 

Abstract

Disrupted circadian rhythms may lead to failures in the control of the cell division cycle and the subsequent malignant cell growth. In order to understand the pathogenesis of cancer more in detail, it is crucial to identify those mechanisms of action which contribute to the loss of control of the cell division cycle. This mini-review focuses on the recent findings concerning the links between the human circadian clock and cancer. Clinical implications concern not only feasible methods for the assessment of the circadian time of an individual or for the determination of the best time for administration of a drug of treatment, but also in the future genetic tests for screening and for planning treatment.

Declaration of interest: The authors report no conflicts of interest.

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