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Abstract
Introduction. Diabetic retinopathy (DR) is a common chronic microvascular diabetic complication. The presence of DR may indicate microcirculatory dysfunction in other organ systems besides visual morbidity. The objective of this study was to develop a simple diabetic retinopathy risk score to identify DR in Chinese overweight/obese patients with type 2 diabetes mellitus (T2DM).
Patients and methods. A multicentre hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. The evaluated 2699 patients included 1263 males and 1436 females, with an average age of 59.4 ± 13.0 years.
Results. The diabetic retinopathy risk score was conducted by age, duration of DM, history of antihypertensive drug treatment, and waist circumference. The area under the receiver operating characteristics curve for DR was 0.700 (95% CI 0.671–0.729). Comparing Youden's index of different values, the optimal cut-off point was 20 to predict DR. The odds ratio for one unit increase in the diabetic retinopathy risk score associated with the risk of DR was 1.104 (95% CI 1.089–1.120).
Conclusions. Our data suggest that the diabetic retinopathy risk score could be a reliable primary screening tool for the presence of DR in Chinese overweight/obese patients with T2DM.
Acknowledgements
The study was supported by the following hospitals: Zhujiang Hospital of Southern Medical University, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, The Second Affiliated Hospital of Shantou University Medical College, The First Affiliated Hospital of Shantou University Medical College, Wu Jing Zong Dui Hospital of Guangdong Province, The People's Hospital of Jiangmen, Jiangmen Central Hospital, The People's Hospital of Shenzhen, Zhongshan People's Hospital, Guangdong General Hospital, Affiliated Hospital of Guangdong Medical College, The first Affiliated Hospital of Clinical Medicine of GDPU, The Second Affiliated Hospital of Guangzhou Medical University, The First Affiliated Hospital of Guangzhou Medical University, The Third Affiliated Hospital of Guangzhou Medical University, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou First Municipal People's Hospital, The First Affiliated Hospital of Jinan University, The Third Affiliated Hospital of Southern Medical University, Guangdong No. 2 Provincial People's Hospital, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou Red Cross Hospital, The 458th Hospital of PLA, Clifford Hospital, Shantou Central Hospital, People's Hospital of Boan District of Shenzhen City, Peking University Shenzhen Hospital, People's Hospital of Futian District of Shenzhen City, The Second People's Hospital of Shenzhen, People's Hospital of Nanshan District of Shenzhen City, Longgang Central Hospital, Chaozhou Central Hospital, The People's Hospital of Dongguan, Shenzhen Donghua Hospital, People's Hospital of Nanhai District of Foshan City, The First People's Hospital of Foshan, Foshan Hospital of Traditional Chinese Medicine, Mingjing Diabetic Hospital of Shunde, The People's Hospital of Heshan, Huizhou Central Hospital, Wuyi Hospital of Traditional Chinese Medicine, The People's Hospital of Xinhui, Xinhui Hospital of Traditional Chinese Medicine, The People's Hospital of Jieyang, Kaiping Central Hospital, Kaiping Hospital of Traditional Chinese Medicine, The People's Hospital of Qingyuan, The People's Hospital of Shanwei, The People's Hospital of Xinxing, The People's Hospital of Yangjiang, The People's Hospital of Yuebei, The People's Hospital of Lechang, The First People's Hospital of Zhaoqing, Chenxinghai Hospital Affiliated to Guangdong Medical College, The Second People's Hospital of Zhuhai, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhongshan Hospital of Traditional Chinese Medicine, Sanxiang Hospital of Zhongshan, Maoming People's Hospital, Meizhou People's Hospital, and Zhongshan Hospital of Traditional Chinese Medicine.
Jiao Wang and Hong Chen contributed equally to this work.
Declaration of interest: The authors do not have any conflict of interest to declare.