Abstract
Introduction This study assessed associations of depression and anxiety with risk of obstructive sleep apnea (OSA) among non-Hispanic blacks in the Metabolic Syndrome Outcome (MetSO) study.
Method A total of 1,035 patients participated. ARESTM score ≥6 defined high OSA risk. Moderate depression was defined by a CES-D score ≥16. Moderate anxiety was measured by a BAI score ≥16.
Results The mean age was 62 ± 14 years; 70% were female. A total of 93% were diagnosed with hypertension; 61%, diabetes; and 72%, dyslipidemia; 90% were overweight/obese; 33% had a history of heart disease; and 10% had a stroke. Logistic regression analysis, adjusting for age and gender, showed that patients with depression had nearly two-fold increased odds of being at risk for OSA (OR 1.75, 95% CI 1.02–2.98, p < 0.05). Patients with anxiety had three-fold increased odds of being at risk for OSA (OR 3.30, 95% CI 2.11–5.15, p < 0.01). After adjusting for marital status and income, patients with anxiety had a 6% increase in OSA risk (OR 1.06, 95% CI 1.04–1.09, p < 0.05), but depression was no longer significant.
Conclusion Our results suggest that non-Hispanic blacks with metabolic syndrome who experience anxiety and/or depression should be screened for OSA.
This study assessed associations of moderate to severe depression and anxiety with risk of obstructive sleep apnea (OSA) among non-Hispanic blacks with metabolic syndrome.
Patients with depression had nearly two-fold increased odds of being at risk for OSA.
Patients with anxiety had three-fold increased odds of being at risk for OSA.
Key messages
Declaration of interest
The authors report no conflicts of interest.
This research was supported by funding from the National Institutes of Health: R25HL105444, R01HL095799, RO1MD004113, and U54NS081765. The funding source had no role in the design, conduct, or analysis of the study, or in the decision to submit the manuscript for publication.