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Annals of Medicine Volume 27, 1995 - Issue 3
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Miscellaneous Article

Nitric Oxide: Biological Mediator, Modulator and Effector

Marek W. Radomski Departments of Obstetrics and Gynaecology and Pharmacology, Perinatal Research Centre, University of Alberta, Edmonton AB, Canada
Pages 321-329 | Published online: 08 Jul 2009
 
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Abstract

Nitric oxide (NO) is synthesized from L-arginine by at least three isoforms of NO synthase enzyme (NOS). Once generated NO can interact with a number of molecular targets including haem proteins, enzymes, DNA, thiols, oxygen and superoxide. These reactions determine the profile of NO as a major biological mediator, modulator and effector molecule.

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