Serum lipid/lipoprotein and arterial blood pressure among Chinese nonagenarians/centenarians

Abstract

Objective. In the present study, we detected a relationship between serum lipid/lipoprotein [serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol] and arterial blood pressure among Chinese nonagenarians/centenarian. Methods. The present study analyzed data from the survey that was conducted on all residents aged 90 years or more in a district; there were 2,311,709 inhabitants in 2005. Arterial blood pressure included systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results. The subjects included in the statistical analysis were 217 men and 444 women. Subjects with hypertension (1.29 ± 0.74 vs 1.13 ± 0.45, t = 3.362, p = 0.001) or systolic hypertension (1.30 ± 0.74 vs 1.12 ± 0.45, t = 3.534, p < 0.0001) had higher levels of TG than those without. Subjects with abnormal levels of serum TG had higher SBP (145 ± 22 vs 139 ± 23, t = 2.223, p = 0.027). The Pearson correlation showed a significant relationship between SBP and serum TG levels (r = 0.088, p = 0.024). Unadjusted and adjusted multiple logistic regressions showed that hypertension or systolic hypertension was associated with an increased risk of abnormal of serum TG levels. Conclusions. In summary, we found that among Chinese nonagenarians and centenarians, the levels of serum lipid/lipoprotein were associated with arterial blood pressure. Hypertriglyceridemia was associated with SBP.

Key Words::

• Arterial blood pressure
• nonagenarians/centenarians
• serum lipid/lipoprotein

Acknowledgements

This work was supported by the Discipline Construction Foundation of Sichuan University and by grants from the Project of Science and Technology Bureau of Sichuan Province (2006Z09-006-4), and the Construction Fund for Subjects of West China Hospital of Sichuan University (XK05001). The authors thank the staff of the Department of Geriatrics Medicine, West China Hospital and Dujiangyan Hospital, and all participants (as well as their legal proxies) for their great contribution.

Conflicts of interest

None.