Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns

Abstract

Objective. The 1936G AKAP10 allele is associated with increased adult basal heart rate (HR) and decreased variability, markers of low cholinergic/vagus sensitivity associated with hypertension. Blood pressure (BP) values in newborns are important measurable markers of cardiovascular risk later in life. The question was whether decreased vagal function-related 1936A > G AKAP10 is associated with newborn BP. Study design. 114 healthy Polish newborns born after 37th gestational week to healthy women with uncomplicated pregnancies. At birth, newborn cord blood obtained for isolation of genomic DNA. BP and HR measured on days 1 and 3 after delivery. Results. Diastolic BP on day 3 and absolute and relative differences between diastolic BP values, as well as between mean BP values on day 3 and on day 1 after birth, in carriers of 1936G AKAP10 allele, were significantly higher as compared with wild-type homozygotes. Conclusion. Results demonstrate possible association between 1936G AKAP10 variant and BP in Polish newborns.

Key Words::

• 1936G AKAP10 allele
• cardiovascular risk
• diastolic blood pressure
• gene polymorphism
• heart rate

Acknowledgements

We wish to acknowledge helpful advice from Prof. Timothy Spector and Juliette Harris, Ph.D., from the Department of Twin Research & Genetic Epidemiology, King's College London, UK. This study was funded entirely by the Pomeranian Medical University, Szczecin, Poland.

Disclosure

The authors declare no conflict of interest.