Genetic polymorphisms of myeloperoxidase and their effect on hypertension

Abstract

Myeloperoxidase (MPO) is a member of the mammalian peroxidase superfamily and plays specific roles in host defense. This study aimed to explore the association between one polymorphism of MPO and hypertension risk. Study subjects were recruited from Taipei City Hospital, Zhongxiao Branch, Taipei Medical University Hospital and Taipei Municipal WanFang Hospital. Participants completed questionnaires and provided blood samples. In this study we considered hypertension to be present among subjects that had blood pressures above 140/90 mmHg, or who had previously received treatment for hypertension. The polymorphism of MPO investigated in this study was constructed by performing a restriction fragment length polymorphism following polymerase chain reaction. This study found the odds ratio and 95% confidence interval for hypertension among subjects with the MPO -463 GA/AA genotype to be 1.97 (1.23–3.16) when compared with those with the GG genotype after multivariate adjustment. Participants with a body mass index (BMI) ≥ 24 kg/m² and with MPO -463 GA/AA genotype had a 4.60-fold increased risk of hypertension compared with those with a BMI < 24 kg/m² and with the GG genotype. This is the first study to conclude that the MPO -463 GA/AA genotype was associated with hypertension. In addition, we also detected that subjects with the MPO -463 GA/AA genotype that had higher BMIs and positive diabetes status tended to have higher risks of hypertension than subjects with the MPO -463 GA/AA genotype that had normal BMIs and were not diabetic.

Key Words::

• Hypertension
• myeloperoxidase
• polymorphism

Conflict of interest

We disclosed all financial and interpersonal relationships that could be viewed as presenting a potential conflict of interest.

The study was supported by grant from The study was supported by grants from the National Science Council of the ROC (NSC92-3112-B-038-001, NSC92-2321-B-038-004, NSC93-2321-B-038-012, NSC93-3112-B-038-001, NSC94-2314-B-038-023, NSC-95-2314-B-038-007, NSC-96-2314-B038-003, NSC 97-2314-B-038-015-MY3 (1-3), NSC 97-2314-B-038-015-MY3 (2-3) and NSC 97-2314-B-038-015-MY3 (3-3)).