Pelvic–ureteric junction obstruction and hypertension with target organ damage: A case report and review of the literature

Abstract

Pelvic–ureteric junction obstruction (PUJO) is rare in adults and may be seen when the diagnosis has been missed in childhood. Hypertension may be a feature of PUJO but limited data are currently available in literature to support its association. We report a case of a 29-year-old woman who presented with severe hypertension. Work-up to exclude secondary hypertension showed high plasma renin activity, and imaging by ultrasound and computerized tomography a hydronephrosis and PUJO with impairment of kidney drainage at the renal scintigraphy. After double-J ureteric stenting, blood pressure decreased, antihypertensive medication tapered and the patients was normotensive with no antihypertensive medications after 6 months. We provide an update of the pathophysiology of hypertension in PUJO and a review of the available literature in order better to define the available treatments for these patients.

Key Words::

• Hydronephrosis
• hypertension
• pelvic–ureteric junction obstruction
• renin

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.