Effectiveness of buprenorphine maintenance treatment as compared to a syringe exchange program among buprenorphine misusing opioid-dependent patients

Abstract

Aims: To investigate the effectiveness of buprenorphine maintenance treatment (BMT) among opioid dependents who are mainly misusing buprenorphine intravenously. Methods: The study was a prospective naturalistic follow-up with a non-randomized control group. In Finland, 30 opioid dependents reporting previous misuse of buprenorphine and participating in the outpatient BMT and 30 matched controls participating in a syringe exchange program (SEP) were followed. Based on the evidence for the superiority of maintenance treatment, randomization was not done. The effectiveness was evaluated by retention rate, European Addiction Severity Index (EuropASI) interviews, Beck Depression Inventory (BDI), visual analogue scale for quality of life (VAS) during the 2-year follow-up and mortality rates during the 3-year follow-up. Because of drop-outs in the SEP group, only the BMT group was interviewed at 24 months. Results: At 3 months, the retention rate of the BMT group was 100% and of the SEP group 47%. At 12 months, the corresponding percentages were 83% and 37%. The total EuropASI composite score improved significantly only in the BMT group. In the BMT group, the BDI total score and VAS scales for quality of life improved significantly more than they did in the SEP group. During 3-year follow-up, four patients in the SEP died and none in the BMT. Conclusions: BMT appears to be an effective treatment for opioid dependents using mainly buprenorphine intravenously. On the other hand, bare SEP appears to result in high drop-out, not significant improvements and deaths.

• Buprenorphine
• Maintenance treatment
• Opioid dependence
• Syringe exchange program

Acknowledgements

We would like to thank the staff of the A-Clinic of Kymi, Eeva-Kaisa Rautiainen and Maarit Raukola for their cooperation and valuable help. This study was made possible by intellectual and motivational support from the “Katkolla tulevaisuus” Association. The study was financially support by Finland's Slot Machine Association (RAY) and by the Yrjö Jahnsson Foundation.

Declaration of interest: M. Aalto has been financially supported to attend two scientific conferences and has given one lecture sponsored by Schering-Plough. J-P Visapää has been financially supported to attend two scientific conferences and has given three lectures sponsored by Schering-Plough.