Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

P. Guinan Division of Cellular Biology of the Hektoen Institute for Medical Research, Department of Urology of the University of Illinois, and the Departments of Urology and Biochemistry of the Rush Presbyterian St. Lukes Medical Center, Chicago, Illinois, 60612.

M. Shaw Division of Cellular Biology of the Hektoen Institute for Medical Research, Department of Urology of the University of Illinois, and the Departments of Urology and Biochemistry of the Rush Presbyterian St. Lukes Medical Center, Chicago, Illinois, 60612.

M. Rubenstein Division of Cellular Biology of the Hektoen Institute for Medical Research, Department of Urology of the University of Illinois, and the Departments of Urology and Biochemistry of the Rush Presbyterian St. Lukes Medical Center, Chicago, Illinois, 60612.

Abstract

Tumor infiltrating lymphocytes (TIL) are increasingly employed in immunotherapy protocols. When modified and expanded they can be utilized in new therapeutic protocols. TIL augmentation can be in vitro and in vivo. The purpose of this article is to review the various methods of TIL augmentation and report our experience with a neoadjuvant technique of cyclophosphamide immunopriming of TILs.

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Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

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Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

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