The Effect of Surgical Wide Excision and Amniotic Membrane Transplantation with Adjuvant Topical Mitomycin C Treatment in Recurrent Conjunctival--Corneal Intraepithelial Neoplasia

Abstract

Purpose: To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival–corneal intraepithelial neoplasia (CCIN). Methods: The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival–corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year. Results: Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months. Conclusions: Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.

• Aamniotic membrane transplantation
• corneal opacity
• recurrent conjunctival–corneal intraepithelial neoplasia (CCIN)
• surgical wide excision
• topical mitomycin C

Notes

*This work was supported by a National Research Foundation of Korea Grant founded by the Korean Government (2012038648).