Fatty Acids and Immune Function: Relevance to Inflammatory Bowel Diseases

Abstract

Fatty acids may influence immune function through a variety of mechanisms; many of these are associated with changes in fatty acid composition of immune cell membranes. Eicosanoids produced from arachidonic acid have roles in inflammation and immunity. Increased membrane content of n-3 fatty acids results in a changed pattern of production of eicosanoids, resolvins, and cytokines. Changing the fatty acid composition of immune cells also affects T cell reactivity and antigen presentation. Little attention has been paid to the influence of fatty acids on the gut-associated lymphoid tissue. However, there has been considerable interest in fatty acids and gut inflammation.

Keywords :

• arachidonic acid
• eicosapentaenoic acid
• docosahexaenoic acid
• fish oil
• inflammation
• eicosanoid
• cytokine
• macrophage
• lymphocyte