Dendritic Cells in Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and environmental factors. There have been several immune mediators linked to SLE including cytokines and chemokines that have been reviewed elsewhere []. A number of articles have reviewed the role of B cells and T cells in SLE []. Here, we focus on the role of dendritic cells (DC) and innate immune factors that may regulate autoreactive B cells.

Keywords :

• dendritic cells
• lupus
• interferon
• autoimmunity

ACKNOWLEDGMENTS

This work is partly supported by NIAID AI50736. We thank Dr. Stephen H. Clarke for helpful suggestions and consultations.