A Case of Progressive Hypertension Preceding Gemcitabine-Associated Thrombotic Microangiopathy Complicated by Acute Kidney Injury and Stroke

Abstract

Gemcitabine-associated thrombotic microangiopathy is being increasingly recognized as a serious complication of treatment. We report a normotensive patient who developed progressive hypertension after commencing gemcitabine therapy. She also developed subtle changes in her platelet count and serum creatinine months before her emergent presentation. Clinicians should be aware of new onset or worsening hypertension and ‘mild’ biochemical changes in gemcitabine-treated patients.

Keywords:

• gemcitabine-associated thrombotic microangiopathy