Vitamin E-coated cellulose acetate dialysis membrane: long-term effect on inflammation and oxidative stress

Abstract

Background: Chronic inflammation and oxidative stress are prevalent in hemodialysis (HD) patients. We evaluated the long-term effect of a vitamin E-coated cellulose acetate (CAE) membrane on oxidative stress and inflammation. Methods: Nine patients were switched to CAE membrane for 3 months and then changed back to polysulfone (PS) membrane again for 6 months. Reactive oxygen metabolites and derivatives (d-ROMs), total antioxidant capacity (TAC) and superoxide dismutase (SOD) (oxidative stress biomarkers), high-sensitivity C-reactive protein (Hs-CRP), and interleukin-6 (IL-6) (inflammation biomarkers) were measured. Results: d-ROMs decreased and TAC rose significantly at the end of the study, whereas SOD increased rapidly and immediately after the end of CAE treatment. Hs-CRP and IL-6 levels were significantly lowered at the end of the study. Conclusions: Vitamin E supplementation by vitamin E-coated CAE dialysis membrane suppresses oxidative stress and inflammation.

Keywords:

• hemodialysis
• vitamin E-coated membrane
• oxidative stress
• inflammation

Acknowledgments

This work was presented in abstract form in the XLIV Congress of the European Renal Association-European Dialysis and Transplantation Association, Barcelona, Spain, 21–24 June 2007.

The authors thank all the renal nurses involved in recruitment participants and everyone who took part in the study

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.