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Abstract
To determine the action of acetate in man, 1.7mEq/ml of sodium acetate was infused in 10 patients on chronic hemodialysis. It was administered intravenously in 1.5mEq/min for 5 min followed by 3.8mEq/min for another 5 min. As control, 1.71mEq/ml of sodium chloride was infused in a similar manner.
Following the infusion of sodium acetate, heart rate increased slightly but significantly(p<0.01). Limb blood flow measured in an upper limb by the venous occlusion method, showed an increase in all of them and it was significant p<.0.001). The peripheral vascular resistance(=mean arterial blood pressure/ limb blood flow) showed a significant fall(p <0.001). The analysis of systolic time interval showed a change suggestive of depression of heart function at the end of sodium acetate infusion(p <0.05). Such a vasodilating effect or a change in heart function was not observed following sodium chloride infusion. A depressant action of acetate upon the cardiovascular system may be, therefore, concluded.