Renal Function and Renal Platinum Content in Uninephrectomized Rats Following Cisplatin Administration

Abstract

The changes in renal function and renal platinum content were assessed in uninephrectomized and sham-operated female Wistar rats on the third day after treatment with 2.5 mg/kg BW or 5 mglkg BW cisplatin. Treatment of control and nephrectomized rats with 2.5 mglkg BW cisplatin resulted in indices of renal function which were not significantly different from those of animals which had received no cisplatin, though the renal platinum contents in nephrectomized rats were practically the same as in two-kidney animals given 5 mglkg BW cisplatin. Treatment with 5 mglkg cisplatin resulted in much less severe changes in kidney weight and renal function compared to two-kidney animals, in spite of much more substantial (by 49–58%) platinum accumulation.