Blue Toe Syndrome Associated with Rapidly Progressive Glomerulonephritis: Ultimately Revealed Essential Mixed Cryoglobulinemia

Abstract

The blue toe syndrome is a rare presentation in a number of medical disorders. We report a 35-year-old woman who initially presented with blue toe syndrome and rapidly progressive glomerulonephritis. Essential mixed cryoglobulinemia with vasculitis and renal failure was documented by laboratory tests and renal biopsy. She was on maintenace hemodialysis as renal failure persisted after steroid and immunosuppresive agents therapy. Her gangrenous changes of bilateral toes were autoamputated symmetrically and uneventfully.

Key Words:

• Blue toe syndrome
• Cryoglobulinemia
• Rapidly progressive glomerulonephritis
• Vasculitis