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Clinical Study

Inorganic Phosphorus Homeostasis during the First Hour of Dialysis

, , , &
Pages 562-567 | Received 04 Jan 2011, Accepted 26 Apr 2011, Published online: 10 Jun 2011
 

Abstract

Background/aim: Hyperphosphatemia is a well-recognized complication of chronic kidney disease, and phosphorus kinetics during hemodialysis (HD) remains a vague area of investigation. We studied the inorganic phosphorus homeostasis during the first hour of an HD session. Materials/methods: Twelve patients were studied twice, in two consecutive HD sessions. Total (TPR), extracellular (EPR), and intracellular (IPR) phosphorus mass removal was determined using the direct dialysate quantification (DDQ) method. Alterations of serum inorganic phosphorus (sP), erythrocyte intracellular phosphorus (PERY), and 2,3-diphosphoglycerate (2,3-DPG) concentrations were measured before HD initiation and at 1, 2, 3, 4, 5, 10, 30, and 60 min. Results: The contribution of IPR to TPR was negative in the first 10 min of both HD sessions (–27.2 ± 6.5 and −26.4 ± 58 mmol, respectively, p = ns) while the contribution of the IPR to TPR increased as the time elapsed. Intracellular phosphorus and 2,3-DPG remained almost unchanged during the 60 min of HD session. Conclusions: Unchanged PERY concentration during the first hour of an HD session does not reject the hypothesis of a simultaneous efflux and influx of phosphorus from/to intracellular compartment.

ACKNOWLEDGMENT

The authors thank Mrs. Aleka Papageorgiou for the skilled secretarial assistance.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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