Change in Cardiovascular Disease Status in Peritoneal Dialysis Patients: A 5-Year Single-Center Experience

Abstract

Background: We compared patient characteristics, atherosclerosis, left ventricular hypertrophy, and dialysis practice patterns of peritoneal dialysis (PD) patients with change in cardiovascular disease (CVD) status and no change in CVD status in Chinese PD center. Methods: This study included all patients who started on PD between 1 January 2003 and 30 June 2009 at the Renji Hospital, Shanghai Jiaotong University School of Medicine, China. They were followed up from the date of PD initiation until new-onset CVD. Results: The median follow-up time was 44.13 months. In patients with preexisting CVD, both high triglyceride (1.43 ± 0.89 mmol/L vs. 2.64 ± 1.58 mmol/L, p < 0.001) and the duration of dialysis (45.76 ± 13.28 months vs. 58.68 ± 13.74 months, p < 0.01) were independent predictors of CVD progression and the left atrial dimension, left ventricle septal thickness, left ventricle mass index (LVMI), and intima-media thickness (IMT) also had the difference. On the other hand, in patients without preexisting CVD, the dialysis adequacy and nutritional status are important during the follow-up. Serum albumin in CVD group was lower than in no CVD group (30.86 ± 4.77 g/L vs. 36.04 ± 6.40 g/L, p < 0.05). Creatinine clearance (CCr) and Kt/V in CVD group were lower than in no CVD group (CCr 57.24 ± 13.86 L/week vs. 71.06 ± 23.96 L/week, p < 0.05; Kt/V 1.82 ± 0.41 vs. 2.23 ± 0.57, p < 0.05). Conclusion: In patients with preexisting CVD, it is important to address traditional risk factors such as LVMI, IMT, and lipid profile. In patients without preexisting CVD, we should pay more attention to the nutritional status and PD prescription in order to lower the morbidity of CVD in these PD patients.

• chronic renal failure
• peritoneal dialysis
• cardiovascular disease
• follow-up
• outcome

ACKNOWLEDGMENTS

We would like to thank the doctors of the Renal Division, Renji Hospital Shanghai Jiaotong University School of Medicine, for their work. This work was supported in part by grant [2008] Nos. 49 and 09dZ1973600 from the Shanghai PuDong Society Development Burea, Science and Technology Commission of Shanghai Municipality China. The project was also sponsored by SRF for ROCS, SEM.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.