Coexisting glomerular IgA deposition and IgG-kappa multiple myeloma

Abstract

Multiple myeloma (MM) is a common malignancy that often results in many kinds of kidney injuries for the abnormal monoclonal immunoglobulin. Here, we present an IgG-kappa type MM case accompanied by renal IgA deposition combined with IgG-kappa. The patient was treated with prednisone plus mycophenolate mofetil, and got a satisfactory remission. Although it cannot be determined whether the IgA deposition was secondary to MM, this was the first report of coexisting mesangial proliferative nephritis with IgA deposition and IgG-kappa type MM.

• Immunoglobulin A
• mesangial proliferative nephritis
• multiple myeloma
• proteinuria

Acknowledgements

Thanks to Dr. Marc Casati of Medical College of Wisconsin for English improvement.