Effects of 3-Deazaadenosine, An Inducer of HL-60 Cell Differentiation, on Human Blood Cells in Vitro

Per S. Prytz Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Thrina Loennechen Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Per A. Johansson Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Lars B. Larsen Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Lars Slørdal Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Jarle Aarbakke Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9001, Tromsø, Norway

Abstract

The adenosine analogue 3-deazaadenosine (c³ Ado) induces differentiation of human promyelocytic leukemia HL-60 cells in vitro, c³ Ado affects in vitro viability and growth of cells involved indirectly (cytokine-producing cells) and directly (transformed myeloid cells) in leukemic cell differentiation. Growth inhibition of proliferating cells is achieved at c³ Ado concentrations between 10–100 μM. Concentrations higher than 100 μM affect viability of proliferating and nonproliferating cells.

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Effects of 3-Deazaadenosine, An Inducer of HL-60 Cell Differentiation, on Human Blood Cells in Vitro

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Effects of 3-Deazaadenosine, An Inducer of HL-60 Cell Differentiation, on Human Blood Cells in Vitro

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