Tumor Lysis Syndrome Complicating Treatment of Widespread Metastatic Abdominal Rhabdomyosarcoma

Abstract

In this paper we describe a 9-year-old girl with abdominal embryonal rhabdomyosarcoma. She had ascites and widespread metastatic disease at presentation and was oliguric but had a normal creatinine. Following the start of chemotherapy she developed acute renal failure secondary to the tumor lysis syndrome, requiring hemodialysis, and had considerable myelotoxicity.

Key Words:

• tumor lysis syndrome
• rhabdomyosarcoma
• metabolic emergencies
• metastatic malignancies