Reply: About the Von Willebrand Factor

Abstract

I thank Prof. Özsoylu for his helpful criticism about the paper, “von Willebrand Factor: Biological Function and Molecular Defects.” The von Willebrand factor (vWF) serves two distinct functions: as a cofactor for platelet adhesion to subendothelial matrix molecules, and as the circulating protein that binds and stabilizes procoagulant factor VIII. In the latter function, vWF takes role in blood clotting.