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Original Article

Marine Oils in the Modulation of Colonic Flora and pH: Considerations for Colon Cancer

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Pages 115-122 | Received 21 Jun 1988, Published online: 11 Jul 2009
 

Abstract

BALB/c mice fed high fat diets containing coconut, safflower, or menhaden marine oil were evaluated for faecal flora and faecal pH. Animals fed marine oils showed significantly higher total aerobic Gram-negative rods at 109 CFU/gm, compared with those fed saturated or polyunsaturated fat diets with 106 CFU/gm. Marine oil fed mice exhibited a significantly lower log10 ratio of anaerobes:aerobes at 1.17, compared to the saturated and polyunsaturated fat fed mice at 3.49 and 2.87 respectively. Differences in flora composition were seen, with increased E.coli (109 CFU/gm) for the marine oils group compared to the saturated and polyunsaturated groups, each with 106 CFU/gm. Faecal samples from animals on marine oils exhibited a lower pH (6.1), compared to samples from animals on saturated or polyunsaturated fat with pH of 7.32 and 7.49 respectively, β-glucuronidase levels were also evaluated and showed no significant differences among the different diets.