Effect of Exopolysaccharide V2-7, Isolated from Halomonas Eurihalina, on the Proliferation In Vitro of Human Peripheral Blood Lymphocytes

Abstract

The immunomodulatory activity of the exopolysaccharide V2-7, a sulfated polymer excreted by the moderately halophilic bacteria Halomonas eurihalina, was studied in vitro. [³H]thymidine incorporation and flow-cytometry measurements showed that this exopolysaccharide enhanced the unspecific proliferation of human lymphocytes in response to the presence of anti-CD3 monoclonal antibody. It was effective at concentrations of less than lμg/ml, maximum activity being achieved at 0.2μ-g/ml,