Effects of Lentinan on Cytotoxic Functions of Human Lymphocytes

Gergely Péater Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan

Vallent Káaroly Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan

BodÓA Imre Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan

FehÉAr Jáanos Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan

Yutaro Kaneko Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan

Abstract

The in vitro effects of lentinan on natural killer (NK), antibody-dependent cell-mediated cytotoxicity (ADCC), lectin-dependent cell-mediated cytotoxicity (LDCC) and mitogen-induced blast transformation were studied in patients with solid tumors and chroyic lymphocytic leukemia (CLL). NK activity was measured against Cr-labelled K-562 targets, ADCC against antibody-coated chicken red cells. LDCC and natural cell-mediated cytotoxicity (NCMC) was assessed using ³H-thymidine prelabelled HEp-2 targets. Mitogen (PHA-and Con A-) induced blast transformation was measured by thymidine incorporation.

Blastogenesis and LDCC was not influenced by lentinan. 1 μg/ml lentinan increased NCMC of tumor-bearing subjects. The most prominent enhancement of NK and ADCC activity was seen in CLL patients, where a dose-related increase was seen (from 0.01 to 1 μg/ml).

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Effects of Lentinan on Cytotoxic Functions of Human Lymphocytes

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Effects of Lentinan on Cytotoxic Functions of Human Lymphocytes

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