Inmjnostimjlant Activity of A Novel Lipopeptide and Its Protective Action Against Leishmnia Donovani

A. Puri Division of Biochemistry, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

S. Y. Rizvi Division of Biopolymers, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

W. Haq Division of Biopolymers, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

P. Y Guru Division of Parasitology, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

B. Kundu Division of Biopolymers, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

R. P. Saxena Division of Biochemistry, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

R. Shukla Division of Pharmacology, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

K. B. Mathur Division of Biopolymers, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

K. C. Saxena Division of Biochemistry, Central Drug Research Institute, Post Box No. 173, Lucknow, 226 001, INDIA

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Abstract

Novel lipopeptides 84/201 and 86/450 synthesized in this laboratory stimulated antibody and delayed type hypersensitivity (DTH) response to ovalbumin in guinea pigs. Lipopeptide 86/450 also stimulated antibody and DTH responses in albino mice and enhanced nonspecifically macrophage migration index (fvMI), phagocytic activity and incorporation of [¹⁴C] glucosamine in peritoneal macrophages of the treated animals. Proliferative response of splenocytes from lipopeptide 86/450 treated animals was significantly higher than that from untreated controls. Peritoneal macrophages from lipopeptide 86/450 treated mice were less susceptible to Leishmania donovani promastigote invasion when co-cultured in vitro. the treated animals on challenge with L. donovani promastigote/amastigote showed 80 to 90% lower intake of infection than the control animals.

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Inmjnostimjlant Activity of A Novel Lipopeptide and Its Protective Action Against Leishmnia Donovani

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Inmjnostimjlant Activity of A Novel Lipopeptide and Its Protective Action Against Leishmnia Donovani

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