Study of cardiovascular disease biomarkers among tobacco consumers, part 1: biomarkers of exposure

Abstract

A study was conducted to evaluate biomarkers of biological effect and physiological assessments related to cardiovascular disease (CVD) among adult male cigarette smokers (SMK), moist snuff consumers (MSC) and non-consumers of tobacco (NTC). Additionally, biomarkers of tobacco and tobacco smoke exposure (BoE) were measured in spot urines and are reported here. Except for the BoE to nicotine and NNK, BoE were generally greater in SMK compared with MSC, and BoE were generally not different in comparisons of MSC and NTC. Results demonstrated that MSC had lower systemic exposures to many harmful and potentially harmful constituents than SMK, which is consistent with epidemiological data that indicate a differential in CVD risk between these groups.

• Cigarettes
• clinical study
• CVD
• harmful and potentially harmful constituents
• moist snuff
• spot urines

Acknowledgements

The authors wish to acknowledge and thank David Heavner, Thomas Steichen and Celerion (Lincoln, NE; formerly MSD Pharma Services) for their significant contributions to this study.

Declaration of interest

All authors are current or former employees of R.J. Reynolds Tobacco Company and RAI Services Company and report no conflicts of interest. The authors alone are responsible for the content and writing of this article.