Synthesis of Ag-liposome nano composites

Abstract

Silver nanoparticles were synthesized and stabilized by a simple, environment-friendly method in a liposomes structure. Liposomes were prepared by facing lecithin to the aqueous-phase solutions while stirring vigorously. The ratio of lecithin concentration to silver nitrate (K_Lec/Ag = [Lecithin]/[AgNO₃]) is the influencing factor in the synthesis of silver nanoparticles. The stability, size distribution, and antibacterial properties of synthesized silver nanoparticles were studied by ultraviolet (UV)-visible, dynamic light scattering, and antibacterial assay. The UV spectra indicated a single symmetric extinction peak at 400 nm, confirming the spherical shape of the synthesized silver nanoparticles. A high K_Lec/Ag value leads to a reduction in the intensity of extinction spectra and increases the size of Ag-liposomes nanocomposites. The large Ag-liposomes nanocomposites are transformed to the smaller Ag-liposomes nanocomposites (from 342 to 190 nm) due to sonication treatment. The stabilized silver nanoparticles with various lecithin concentrations showed a good antibacterial activity against Staphylococcus aureus, a Gram-positive bacterium, and Escherichia coli, a Gram-negative bacterium.

Keywords::

• Nanocomposite
• silver nanoparticle
• antibacterial
• liposome