A Simplified Model for Liposome Aggregation and Fusion

Abstract

A simplified model is suggested to describe the aggregation and fusion processes of liposomes. This model is based on three points: a) evaluation of number of clusters and aggregation and fusion sites as a function of time; b) probabilistic analysis of size distribution of clusters and fusion products; c) prediction of the experimental signal chosen to monitor the overall fusion. First attempts to compare this model with the experimental data, obtained with the RET assay, show a satisfactory agreement.