Use of Rituximab for Periocular and Intraocular Mucosa-associated Lymphoid Tissue Lymphoma

Abstract

The clinical efficacy of rituximab therapy in systemic mucosa-associated lymphoid tissue (MALT) lymphoma with both periocular and intraocular involvement is described. Ophthalmic examination and radiologic imaging demonstrated tumor with bilateral periorbital, lacrimal, and subconjunctival infiltration, a pseudohypopyon in one eye, and extensive systemic lymph node involvement. Lymph node biopsy confirmed the pathologic findings of a low-grade MALT lymphoma. The patient had a complete remission within 3 months of starting rituximab therapy. A recurrence 6 months later remitted with a second round of rituximab therapy and the patient remained tumor-free at 1 year.

KEYWORDS::

• Lymphoma
• Rituximab
• Uveitis
• Glaucoma

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.