Pioglitazone reduces central obesity in polycystic ovary syndrome women

Abstract

Objective: Based on the role of polycystic ovary syndrome as a cause of metabolic syndrome with chronic anovulation, obesity, hyperinsulinemia and hyperandrogenism, development of effective treatment for its obesity is a priority. Materials/methods: We designed a study, involving 52 patients of 19–36 years of age, to test the pioglitazone in women with polycystic ovary syndrome. Subjects were assigned to receive pioglitazone for 3 months. Body mass index, waist circumference and hip circumference were measured before and after 3 months of pioglitazone prescription. Results: Fifty patients completed the study. No complication reported during the study period. Waist circumference, hip circumference and waist to height ratio decreased significantly. Body weight and body mass index increased. No significant improvement was seen in acne, acanthosis, hirsutism and menstrual irregularities. Conclusion: Pioglitazone has beneficial effects on central obesity of the patients with polycystic ovary syndrome but other clinical consequences of the syndrome may not improve with the drug.

Keywords::

• Thiazolidinedione
• adipocyte
• insulin resistance

Acknowledgement

We express our gratitude to Dr. Mehrnoosh Doroudchi and Dr. Ali Akbar Asadipooya for their help in editing the article. Asadipooya K: Design the study, participate in performing the test, wrote the article. Kalantar-Hormozi M and Nabipour I: Collect the patients, prescribing the medication and follow up the patients.

Declaration of interest: The study has been sponsored by grant number P/T/78 from vice-chancellor of research of Bushehr University of Medical Sciences. The authors have no conflict of interest.