Metformin, oral contraceptives or both to manage oligo-amenorrhea in adolescents with polycystic ovary syndrome? A clinical review

Stefano PalombaDepartment of Obstetrics and Gynecology, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS Reggio EmiliaItalyCorrespondence[email protected]

Caterina MaterazzoDepartment of Obstetrics and Gynecology, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS Reggio EmiliaItaly;Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro CatanzaroItaly

Angela FalboDepartment of Obstetrics and Gynecology, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS Reggio EmiliaItaly

Francesco OrioDepartment of Endocrinology, Parthenope University of Naples NaplesItaly

Giovanni Battista La SalaDepartment of Obstetrics and Gynecology, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS Reggio EmiliaItaly;University of Modena and Reggio Emilia ModenaItaly

Charles SultanUnité d'Endocrinologie Gynécologie Pédiatriques, Hôpital Arnaud de Villeneuve CHU MontpellierFrance

Abstract

The management of oligo-amenorrhea in adolescent patients with polycystic ovary syndrome (PCOS) represents an important and difficult challenge. Metformin and/or oral contraceptives (OCs) are different strategies widely proposed in these patients. The objective of the current review was to provide an overview on the use of metformin and/or OCs for the management of oligo-amenorrhea in adolescents with PCOS underlining their potential risks and benefits in order to help the clinician to choose the best patients’ tailored treatment.

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Metformin, oral contraceptives or both to manage oligo-amenorrhea in adolescents with polycystic ovary syndrome? A clinical review

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Metformin, oral contraceptives or both to manage oligo-amenorrhea in adolescents with polycystic ovary syndrome? A clinical review

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