Abstract
Among the remarkable progress made in the treatment of hormone-dependent diseases, recently selective steroid receptor modulators (SPRM) have been remarkable tools to improve the prognosis of multiple hormone-dependent cancers (breast, prostate). Because of their remarkable properties, both agonistic and mainly antagonistic, to modulate progesterone action. They have allowed a better understanding of progesterone action and progress in contraception and treatment of abnormal uterine bleeding as well as in the medical treatment of uterine fibroids.
Chinese abstract
在激素依赖性疾病相关治疗方法的研究进展中,近来选择性类固醇激素受体调节剂(SPRM)被认为具有改善多种激素依赖性癌症(乳腺、前列腺)预后的作用。它们具有双重拮抗与主要拮抗的独特性质,从而可调节孕激素的功能。它们还可帮助人们更好地了解孕激素在避孕、异常子宫出血的治疗及子宫肌瘤的药物治疗中的作用机制及过程。