A novel approach to normal responder patient with repeated implantation failures – a case report

Abstract

We describe a case of normal responder patients with repeated implantation failure who was offered the combination of the ultrashort GnRH-ag/ GnRH-ant COH protocol, followed by endometrial injury and a subsequent natural cycle frozen-thawed embryos transfer. The patient conceived following the natural FET cycle that was supported by luteal daily progesterone, with the additional single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively. This combined approach seems to be a valuable tool in the armamentarium for treating normal responder patients with repeated implantation failures and should be further examined in large randomized controlled trials.

• Frozen-thawed embryo transfer
• IVF outcome
• local injury
• mid-luteal GnRH-agonist
• repeated implantation failures
• ultrashort flare GnRH-agonist/GnRH antagonist

Declaration of interest

The authors declare that they have no competing interests. No study funding was achieved.